Kushandiswa kweMicrofluidics muBiomedical Biomedical: Shanduko muHutano
Microfluidics, sainzi netekinoroji yekushandura mvura pa microscale, yave nzvimbo inochinja ine mashandisirwo akawanda ekurapa. Zvakatanga sepfungwa inonakidza mufizikisi neinjiniya zvashanduka kuita puratifomu yakasimba ine mukana wekuchinja hutano, kuongororwa, uye masisitimu ekurapa. Chinyorwa chino chinotarisa mashandisirwo akasiyana-siyana ekurapa kwe microfluidics, ichiratidza kukosha kwayo kukuru pakurapa kwemazuva ano.
Nhanganyaya kuMicrofluidics
Microfluidics inobata maitiro, kudzora kwakarurama, uye kushandura mvura yakaganhurirwa pazviyero zvidiki (zvinowanzova sub-millimeter). Muzviyero izvi, mafambiro emvura anoratidzwa nekuyerera kwemvura, uko nhamba dzaReynolds dziri pasi uye masimba akakora anotonga masimba asina simba. Nzvimbo iyi yakasiyana inobvumira mashandisirwo asingawanikwe mumasisitimu macroscopic, akadai sekusanganisa kwakanyatsodzorwa, kuchinjana kwekupisa nekukurumidza, uye kuongorora kwehuwandu hwemvura.
Kuongorora Nzvimbo Yekutarisira
Imwe yenzira dzinonyanya kuvimbisa dzekuongorora chirwere che microfluidics ndeyekuongorora chirwere chePOC (point-of-care). Nzira dzechinyakare dzekuongorora chirwere dzinowanzoda michina yakaoma yekurabhoritari, nguva yakareba yekugadzirisa chirwere, uye hunyanzvi hwakakosha. Kusiyana neizvi, michina yekuongorora chirwere che microfluidic inogona kuva diki, isingadhuri, uye iri nyore kushandisa, kunyangwe munzvimbo dzisina zviwanikwa zvakawanda.
Mapuratifomu emicrofluidic anogonesa kubatanidzwa kwemaitiro akawanda emurabhoritari, akadai sekugadzirira sampuro, reaction, kupatsanurwa, uye kuona, muchishandiso chimwe chete, chinowanzozivikanwa se "lab-on-a-chip" (LOC). Midziyo iyi inogona kugadzirisa zviri nyore sampuli diki dzezvipenyu, zvichibvumira kuonekwa kwezvirwere nekukurumidza uye zvine hungwaru. Semuenzaniso, masisitimu emicrofluidic akagadzirwa kuti aongorore hutachiona hwakadai seHIV, TB, uye malaria kuburikidza nekuona ma biomarkers chaiwo achishandisa nzira dzakadai se immunoassays uye nucleic acid amplification.
MaModheru eOrgan-on-a-Chip
Mumakore achangopfuura, microfluidics yave kufambira mberi mukugadzira tishu, kunyanya kuburikidza nekugadzirwa kwemamodheru eorgan-on-a-chip (OOC). Aya masisitimu e microengineered anotevedzera hunhu hwemaumbirwo uye mashandiro enhengo dzevanhu. MaOOC anopa data rakakosha pane masisitimu echinyakare ekukura kwemasero maviri kana kunyange mamodheru emhuka, zvichivhara musiyano uripo pakati pezvidzidzo zve in vitro ne in vivo.
Mapapu-pa-chip, chiropa-pa-chip, uye moyo-pa-chip mienzaniso yemamodeli akadaro anotevedzera zvinhu zvakakosha zvemuviri wemunhu uye pathology. Masisitimu aya anobatsira pakudzidza mashandiro ezvirwere, kudyidzana kwemishonga, uye mishonga yemunhu. Semuenzaniso, mapapu-pa-chip anogona kutevedzera mafambiro ekufema kuti adzidze hutachiona hwekufema kana kuongorora mhedzisiro yechepfu yezvinhu zvinofema, nepo chiropa-pa-chip chinogona kutevedzera maitiro ekugadzirisa muviri uye kubvisa chepfu mumishonga.
Kugadzirwa uye Kuongororwa Kwemishonga
Microfluidics inoita basa guru mukuwana nekugadzira mishonga nekugonesa kuongorora mishonga zvakanyanya (HTS) mumaraibhurari emakemikari. Kuwanikwa kwemishonga yechinyakare inzira inotora nguva uye inodhura, yakazara nekukundikana kwakanyanya. Zvisinei, mapuratifomu e microfluidics anorerutsa kuyedzwa kwezviuru zvemakemikari panguva imwe chete, achishandisa mavhoriyamu madiki e reagents nemasampuli, zvichideredza zvakanyanya mari nenguva.
Midziyo yemicrofluidic inobvumirawo kudzora kwakarurama mamiriro ekuyedza uye kugona kuita kutarisa kwemhinduro dzemasero kumishonga panguva chaiyo. Izvi zvakakosha zvikuru pakuona mafomura emishonga akakodzera uye madhigirii, uye pakunzwisisa pharmacokinetics uye pharmacodynamics yemishonga mitsva yekurapa. Pamusoro pezvo, masisitimu aya anogona kubatanidza masero akaomarara kuti aenzanise kudyidzana pakati pemarudzi akasiyana emasero, zvichipa ruzivo rwemhando dzakasiyana dzezvirwere nezviito zvemishonga.
Single-Sero Analysis
Kusiyana kwemasero emuviri kunokonzera matambudziko makuru mukunzwisisa masero akaomarara nezvirwere. Kuongororwa kwemasero rimwe chete, kunogoneswa nehunyanzvi hwe microfluidic, kunobvumira vaongorori kuongorora kusiyana-siyana uye mashandiro emasero ega ega mukati mevanhu. Masisitimu e microfluidic anogona kuparadzanisa nekuongorora masero rimwe chete muhuwandu hwakawanda, zvichiratidza ruzivo rwakakosha nezvemabasa emasero, kuratidzwa kwemajini, uye mamiriro emetabolism.
Kushandiswa kwemasero madiki ema microfluidics kunosanganisira kutsvakurudza nezvegomarara, uko kunobatsira mukuona masero egomarara asingawanzoonekwi, kunzwisisa kusiyana kwegomarara, uye kutevedzera kushanduka kwekusakwanisa kushandisa mishonga. Mukuongorora immunology, zvinogonesa kudzidza kwakadzama kwekudyidzana kwemasero egomarara uye kuziva mhando dzemasero anobatanidzwa mumhinduro dzemagomarara. Kugona kuongorora masero madiki kwakakoshawo pakutsvagisa masero madiki, zvichigonesa kunzwisisa nzira dzekusiyanisa uye kusimbisa kukura kwemishonga yekuvandudza.
Controlled Drug Delivery
Microfluidics inopa kufambira mberi kukuru muhurongwa hwekutumira mishonga hunodzorwa, izvo zvakakosha pakuvandudza kushanda kwekurapa uye kuderedza migumisiro yakaipa. Midziyo yakagadzirwa nemicrofluidics inogona kudzora kuburitswa kwemishonga nekufamba kwenguva, zvichienderana nezvinokonzeresa, kana kunanga kune mamwe matishu kana masero.
Mienzaniso inosanganisira mapombi e insulin akagadzirwa ne microfluidic ekutarisira chirwere cheshuga, ayo anogona kugadzirisa kuburitswa kwe insulin zvichienderana nekutarisa glucose panguva chaiyo. Midziyo ye microfluidic inoshandiswawo pakurapa kenza munzvimbo, uko inogona kuendesa mishonga yekurapa kenza kunzvimbo dzine bundu, zvichideredza chepfu mumuviri. Kubatanidzwa kwema microfluidic systems nezvinhu zvipenyu kunobvumira kugadzirwa kwe nanoparticles dzekutumira mishonga dzakangwara dzinoburitsa mishonga zvichienderana nezvikonzero zvakati, zvakaita sekuchinja kwepH kana enzyme activity.
mhedziso
Mashandisirwo emishonga ye microfluidics mukurapa kwemishonga ye ...
