Basa reCalcitonin muCalcium Regulation
Calcitonin ihormone inogadzirwa nemasero eC (parafollicular) mugland re thyroid. Iyi hormone inoita basa guru mu calcium homeostasis—maitiro anochengetedza huwandu hwecalcium hwakaringana mumuviri. Kunyangwe ingave isinganyanyo kuzivikanwa se parathyroid hormone (PTH), calcitonin ine basa rayo rinokosha mukudzora calcium. Chinyorwa chino chichaongorora basa re calcitonin mukuita uku uye nei calcium balance ichikosha kudaro.
Maumbirwo uye Kugadzirwa kweCalcitonin
Calcitonin ihormone yepolypeptide inoumbwa nemaamino acids makumi matatu nemaviri. Yakatanga kuwanikwa mukutanga kwema1960 uye kubvira ipapo yave iri chinangwa chekutsvagurudza kwakakura, kunyanya maererano nebasa rayo mukugadzirwa kwemapfupa necalcium. Calcitonin inoburitswa zvakanyanya nemasero eparafollicular egland rethyroid, asi mune dzimwe mhuka, inogonawo kugadzirwa nedzimwe gland.
Mabasa Makuru eCalcitonin
Basa guru re calcitonin nderekudzikisa huwandu hwecalcium muropa (hypocalcemia) kana hwanyanya kuwanda. Calcitonin inoita izvi nenzira dzakasiyana-siyana:
1. Kudziviswa Kwekudhonzwa Kwemapfupa: Calcitonin inodziviswa kushanda kwemasero emapfupa, ayo anokonzera kudhonzwa kwemapfupa. Kana maosteoclast akadziviswa, maitiro ekuputsika kwematrix emapfupa anononoka, zvichireva kuti calcium haidzoserwe muropa nekukurumidza. Izvi zvinoderedza kuwanda kwecalcium muropa.
2. Kuwedzera Kubuda kweCalcium muItsvo: Calcitonin inowedzerawo kubuda kwecalcium muweti nekuderedza kudzoserwa kwecalcium muitsvo. Izvi zvinoreva kuti calcium yakawanda inoseferwa kubva mumuviri muweti, izvo zvinoderedza huwandu hwecalcium muropa.
3. Kuderera kweKutorwa kweCalcium muMatumbu: Kunyangwe izvi zvisina simba sezvakaita pamapfupa neitsvo, calcitonin inogonawo kukanganisa kutorwa kwecalcium mudumbu kubva muchikafu. Izvi zvinoderedza huwandu hwecalcium inopinda muropa kubva mudumbu, zvichibatsira kuderedza huwandu hwecalcium muropa.
Calcitonin neParathyroid Hormone (PTH)
Kuti unzwisise zvizere mashandiro e calcitonin, zvakakosha kunzwisisa hukama hwayo ne parathyroid hormone (PTH). PTH inoshanda kuwedzera huwandu hwe calcium muropa nekukurudzira kusvetwa kwemapfupa uye kuwedzera kusvetwa kwe calcium muitsvo uye kusvetwa muura. Zvakanaka, PTH ne calcitonin zvinoshanda zvakaenzana kuchengetedza huwandu hwe calcium hwakagadzikana.
Kana huwandu hwecalcium muropa hukakwira, thyroid gland inopindura nekuwedzera kuburitswa kwe calcium kuti ideredze. Kusiyana neizvi, kana huwandu hwecalcium muropa hukadzikira, parathyroid glands inopindura nekuwedzera kuburitswa kwePTH kuti iwedzere. Iyi sisitimu inoshanda senzira yekudzora mhinduro yakakosha kune calcium homeostasis.
Kukosha kweKliniki uye Mashandisirwo Ekurapa
Calcitonin ine mabasa akawanda akakosha mukurapa, kunyanya mukurapa zvirwere zvemapfupa zvine chekuita nekuchinja kwehuwandu hwecalcium. Heano mamwe mamiriro ezvinhu apo calcitonin inoshandiswa pakurapa:
1. Kurapa Osteoporosis: Calcitonin inogona kushandiswa kurapa osteoporosis, chirwere chinoratidzwa nekudzikira kwehuremu hwemapfupa uye kuwedzera kwenjodzi yekutyoka. Calcitonin inogona kubatsira kuderedza kusveta kwemapfupa, nokudaro ichichengetedza huremu hwemapfupa uye kuderedza njodzi yekutyoka.
2. Hypercalcemia: Calcitonin inogona kushandiswawo kurapa hypercalcemia (huwandu hwakawanda hwecalcium muropa), iyo inogona kunge iri dambudziko rehutano. Nekudzivisa kusvetwa kwemapfupa uye kuwedzera calcium inoburitswa mumuviri, calcitonin inogona kubatsira kuderedza huwandu hwecalcium muropa nekukurumidza.
3. Chirwere chePaget: Chirwere ichi chinosanganisira kusveta mapfupa zvakanyanya, zvichikonzera kuremara uye kushaya simba kwemapfupa. Calcitonin inogona kubatsira nekudzivisa kushanda kweosteoclast, nokudaro ichideredza kusveta mapfupa zvakanyanya.
Gakava neTsvagiridzo Zvichangobva Kuitika
Kunyange hazvo mabhenefiti ekurapa e calcitonin achizivikanwa zvakanyanya, pane gakavawo pamusoro pekushanda kwayo uye kuchengetedzeka kwayo kwenguva refu. Ongororo dzinoverengeka dzichangoburwa dzakaratidza kuti kushandisa calcitonin zvakanyanya kunogona kukonzera njodzi, kusanganisira kuwedzera kwenjodzi yekenza nekushandisa kwenguva refu. Saka, mumakore achangopfuura, kwave nekumanikidzwa kutsvaga dzimwe nzira kana kuona kuti calcitonin inoshandiswa chete mumamiriro ezvinhu akakosha uye nekutarisa kwakanyatsojeka.
Pamusoro pezvo, tsvakiridzo iri kuenderera mberi kuti inzwisise zvizere mashandiro anoita calcitonin, kusanganisira kugona kwayo kurapa mamwe mamiriro anosanganisira calcium nemapfupa, akadai serheumatoid arthritis nekenza inokanganisa mapfupa.
Calcitonin muChimiro Chakakura cheBiological
Zvakakosha kuona basa re calcitonin nenzira yakafara yehupenyu. Calcium imineral inokosha inoita mabasa akasiyana-siyana akakosha mumuviri, kusanganisira kusimba kwetsandanyama, kugonya ropa, uye kushanda kwetsinga. Nokudaro, calcium homeostasis yakakodzera inokosha pahutano hwese.
Kubatanidzwa kweCalcitonin mukudzora calcium muropa chikamu chekubatana kwemahormone nemaitiro anoshanda pamwe chete kuchengetedza mashandiro akanaka emuviri mumuviri. Kunyange zvazvo isiri iyo chete hormone inodzora calcium, calcitonin inopa imwe nhanho yekudzivirira kubva pakuchinja-chinja kwemazinga ecalcium kunogona kukanganisa.
Mhedziso
Calcitonin ihormone inokosha inobatsira kudzora huwandu hwecalcium mumuviri kuburikidza nenzira dzakasiyana-siyana, dzinosanganisira kudzivirira kunyungudika kwemapfupa nemapfupa emapfupa, kuwedzera kuburitswa kwecalcium muitsvo, uye kuderedza kunyungudika kwecalcium muura. Kunyangwe ichionekwa seisingakoshi pane parathyroid hormone, calcitonin inoita basa rakakosha mukuona kuti calcium yakaenzana inodiwa kuti muviri ushande zvakanaka.
Mabhenefiti ekurapa e calcitonin akashandiswa kurapa zvirwere zvakasiyana-siyana zvine chekuita nemapfupa ne calcium, kunyange hazvo kushandiswa kwayo kuchifanira kuitwa nekungwarira kudzivirira migumisiro isingadiwe. Tsvagiridzo iri kuramba ichinyatsonzwisisa mabasa akasiyana-siyana e calcitonin uye kugona kwayo kurapwa.
Saka, calcitonin inopa muenzaniso wakakwana wekuti mahormone emuviri anoshanda sei pamwe chete kuchengetedza homeostasis uye hutano hwemuviri wese.
