Ọrụ nke Calcitonin na Nchịkwa Calcitonin
Calcitonin bụ homonụ nke mkpụrụ ndụ C (parafollicular) na-emepụta n'ime gland thyroid. Homonụ a na-arụ ọrụ dị oke mkpa na homeostasis nke calcium—usoro nke na-eme ka ọkwa calcium dị n'ahụ dị mma. Ọ bụ ezie na a naghị ama ya nke ọma dịka parathyroid hormone (PTH), calcitonin nwere ọrụ dị mkpa nke ya na nhazi calcium. Isiokwu a ga-enyocha ọrụ calcitonin na usoro a na ihe kpatara nguzozi calcium ji dị oke mkpa.
Nhazi na Mmepụta nke Calcitonin
Calcitonin bụ homonụ polypeptide nke nwere amino acid iri atọ na abụọ. A chọpụtara ya na mbụ na mbido afọ 1960, kemgbe ahụkwa ọ bụ ya mere nnyocha sara mbara ji aga n'ihu, ọkachasị gbasara ọrụ ya na nhazi ọkpụkpụ na calcium. A na-emepụta Calcitonin site na mkpụrụ ndụ parafollicular nke gland thyroid, mana n'ime ụfọdụ anụmanụ, gland ndị ọzọ nwekwara ike imepụta ya.
Isi Ọrụ nke Calcitonin
Isi ọrụ nke calcitonin bụ ibelata ọkwa calcium dị n'ọbara (hypocalcemia) mgbe ha dị oke elu. Calcitonin na-eme nke a site na ọtụtụ usoro:
1. Mgbochi Mwepụ Ọkpụkpụ: Calcitonin na-egbochi ọrụ nke osteoclasts, mkpụrụ ndụ ndị na-akpata mwepụ ọkpụkpụ. Mgbe a na-egbochi osteoclasts, usoro mmebi ọkpụkpụ na-ebelata, nke pụtara na calcium anaghị ahapụghachi n'ọbara ngwa ngwa. Nke a na-ebelata mkpokọta calcium na serum ọbara.
2. Mmụba nke Calcium na-apụta n'ime akụrụ: Calcitonin na-emekwa ka calcium na-apụta n'ime mmamịrị site n'ibelata nnabata calcium na akụrụ. Nke a pụtara na a na-ewepụ calcium karịa n'ahụ mmadụ na mmamịrị, nke na-ebelata ọkwa calcium dị n'ọbara.
3. Mbelata Mmịpụta Calcium n'ime afọ: Ọ bụ ezie na mmetụta a adịghị ike dịka ọ dị n'ọkpụkpụ na akụrụ, calcitonin nwekwara ike imetụta mmịpụta calcium n'ime eriri afọ site na nri. Nke a na-ebelata oke calcium na-abanye n'ọbara site na eriri afọ, na-enyere aka belata ọkwa calcium n'ọbara.
Mmiri Calcitonin na Parathyroid (PTH)
Iji ghọta nke ọma ọrụ nke calcitonin, ọ dị mkpa ịghọta mmekọrịta ya na hormone parathyroid (PTH). PTH na-arụ ọrụ iji mee ka ọkwa calcium dị n'ọbara dịkwuo elu site n'ịkpalite mmịpụta ọkpụkpụ na ịbawanye mmịpụta calcium n'ime akụrụ na ịmịpụta n'ime eriri afọ. N'ụzọ kacha mma, PTH na calcitonin na-arụ ọrụ n'otu n'otu iji nọgide na-enwe ọkwa calcium kwụsiri ike.
Mgbe ọkwa calcium dị n'ọbara rịrị elu, gland thyroid na-aza site n'ịbawanye mmepụta calcitonin iji belata ha. N'aka nke ọzọ, mgbe ọkwa calcium dị n'ọbara dara, gland parathyroid na-aza site n'ịbawanye mmepụta PTH iji bulie ha elu. Sistemụ a na-arụ ọrụ dị ka usoro njikwa nzaghachi dị mkpa maka homeostasis calcium.
Mkpa Ọgwụ na Ojiji Ọgwụgwọ
Calcitonin nwere ọtụtụ ihe dị mkpa e ji agwọ ọrịa ọkpụkpụ, ọkachasị n'ọgwụgwọ ọrịa ọkpụkpụ nke gụnyere mgbanwe ọkwa calcium. Lee ụfọdụ ọnọdụ ebe a na-eji calcitonin agwọ ọrịa:
1. Ọgwụgwọ Ọkpụkpụ Ọkpụkpụ: Enwere ike iji Calcitonin gwọọ ọkpụkpụ ọkpụkpụ, nke a na-akpọ ọrịa ọkpụkpụ ọkpụkpụ nke na-ebelata njupụta ya na mmụba nke ohere nke mgbawa ọkpụkpụ. Calcitonin nwere ike inye aka belata mmịpụta ọkpụkpụ, si otú a na-eme ka ọkpụkpụ dị arọ ma belata ohere nke mgbawa ọkpụkpụ.
2. Hypercalcemia: A pụkwara iji Calcitonin gwọọ hypercalcemia (oke calcium dị n'ọbara), nke nwere ike ịbụ ihe mberede ahụike. Site n'igbochi mmịpụta ọkpụkpụ na ịbawanye mwepụ calcium, calcitonin nwere ike inye aka belata ọkwa calcium dị n'ọbara ngwa ngwa.
3. Ọrịa Paget: Ọnọdụ a gụnyere oke mmịpụta ọkpụkpụ, nke na-ebute nkwarụ na adịghị ike ọkpụkpụ. Calcitonin nwere ike inye aka site n'igbochi ọrụ osteoclast, si otú a na-ebelata oke mmịpụta ọkpụkpụ.
Esemokwu na Nnyocha Ndị Na-adịbeghị Anya
Ọ bụ ezie na a maara uru ọgwụgwọ nke calcitonin nke ọma, e nwekwara arụmụka gbasara irè ya na nchekwa ogologo oge. Ọtụtụ nnyocha ndị e mere n'oge na-adịbeghị anya egosila na iji calcitonin gabiga ókè nwere ike ibute ihe egwu, gụnyere ohere ịbawanye nke kansa ma ọ bụrụ na ejiri ya ogologo oge. Ya mere, n'afọ ndị na-adịbeghị anya, a na-achọ ụzọ ọzọ ma ọ bụ hụ na ejiri calcitonin naanị n'ọnọdụ dị oke mkpa yana nlekota anya nke ọma.
Tinyere nke a, a na-eme nnyocha iji ghọta nke ọma otu calcitonin si arụ ọrụ, gụnyere ike ya n'ịgwọ ọrịa ndị ọzọ metụtara calcium na metabolism ọkpụkpụ, dịka ọrịa ogbu na nkwonkwo na ọrịa kansa ndị na-emetụta ọkpụkpụ.
Calcitonin n'ime usoro ihe ndị dị ndụ sara mbara
Ọ dị mkpa ileba anya n'ọrụ calcitonin n'ime ihe gbasara ihe ndị dị ndụ. Calcium bụ mineral dị mkpa nke na-arụ ọtụtụ ọrụ dị mkpa n'ahụ, gụnyere mkpụkọ akwara, mkpụkọ ọbara, na ọrụ akwara. Ya mere, ezigbo calcium homeostasis dị oke mkpa maka ahụike zuru oke.
Ntinye aka Calcitonin na nhazi calcium n'ọbara bụ akụkụ nke njikọ dị mgbagwoju anya nke homonụ na usoro ndị na-arụkọ ọrụ ọnụ iji nọgide na-arụ ọrụ ahụike zuru oke n'ahụ. Ọ bụ ezie na ọ bụghị naanị homonụ nke na-achịkwa calcium, calcitonin na-enye nchekwa ọzọ megide mgbanwe nwere ike imebi ọkwa calcium.
Mmechi
Calcitonin bụ homonụ dị mkpa nke na-enyere aka ịchịkwa ọkwa calcium n'ahụ site na usoro dị iche iche, gụnyere igbochi mmịpụta ọkpụkpụ site na osteoclasts, ịbawanye mwepụta calcium site na akụrụ, na ibelata nnabata calcium n'ime eriri afọ. Ọ bụ ezie na a na-ewere ya dị ka ihe na-adịghị mkpa karịa parathyroid hormone, calcitonin na-arụ ọrụ dị mkpa n'ịhụ na nguzozi calcium dị mkpa maka ọrụ ahụike ahụ.
A na-eji uru ọgwụgwọ nke calcitonin agwọ ọrịa dị iche iche metụtara ọkpụkpụ na calcium, ọ bụ ezie na a ga-akpachara anya iji ya zere mmetụta ọjọọ ndị a na-achọghị. Nnyocha na-aga n'ihu na-aghọta nke ọma ọrụ dị iche iche nke calcitonin na ikike ya maka ọgwụgwọ.
Ya mere, calcitonin na-enye ihe atụ zuru oke nke otu homonụ bayọlọji si arụ ọrụ n'otu iji nọgide na-enwe homeostasis na ahụike ahụ dum.
